When Jazmine Garcia first started microdosing a compound GLP-1 in February 2025, there was one thing she definitely wanted to avoid: losing too much muscle. The fitness-turned-lifestyle content creator talked it over in depth with her doctor and also did her own research on ways to avoid this common downside of these drugs.
"Unfortunately, rapid weight loss doesn't differentiate between fat and muscle," says muscle physiologist Nima Alamdari, PhD. Research suggests that roughly 25 to 40 percent of weight loss during GLP-1 therapy can come from lean mass.
As alarming as that might sound, part of that loss could be due to shifts in fluid balance, according to the Mayo Clinic, since lean mass also includes body water, organs, and connective tissue. Some research also points to the possibility that what's lost is lower-quality muscle that's infiltrated with fat and doesn't contract well anyway.
Plus, this effect isn't unique to GLP-1s — just about anytime people lose a significant amount of weight, they naturally lose some muscle. — Jennifer Heimlich
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